maintect GmbH provides a specialized platform for the development of lateral flow assays (LFA) based on body fluids, to be used in the development of our own diagnostic products and for contract research. Furthermore, maintect GmbH is currently developing a new alternative AMD treatment option and the company can provide contract work for immune therapy based on our existing expertise in the area of antibody drug development.
.
AMD biomarker autoantibodies may be found in both tears and blood. Blood has evident disadvantages in terms of invasive sampling prior to testing. In addition, high protein concentrations seriously affects assay sensitivity and are a constant problem for blood-based assays. At maintect GmbH, we have been developing a saliva-based sampling system which offers advantages by being quick and non-invasive. The system we are developing permits neutralization of the inhibition exerted by saliva on the test line signal.
- product development
- Companion Diagnostic for AMD treatment using rapid test (lateral flow test)
- further diagnostic products
- contract research:
- LFT diagnostic (body fluids e.g. saliva, tears)
Antibodies in the panel of dry or wet AMD are promising targets to be tested as new therapeutic options for non-responders to current treatment options. This applies not only to whole antibodies, but also to appropriate paratope sequences (CDR-sequences) of the antibody of choice or other related drug targets in the pathways influenced by those marker molecules found in both clinical trials. Paratope sequences could be sequenced and synthesized more easily and would offer a more cost-effective alternative to antibody treatment. Thus, the immunological changes determined in AMD patients offer a way to personalize therapy in order to offer each patient the most promising treatment.
- product development:
- new antibody treatment for AMD
- contract research:
- immune therapy for occular diseases
At maintect GmbH, we also offer our services to meet your needs:
- Extensive experience in the development of lateral flow assays.
- Collaboration in the development of assays based on our saliva collection and strip application system.
- Experience with multiplex LFA for detection of different substances from a single sample.
- Software and hardware for the optical analysis of multiplex systems.